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Despite the promising progress in subject-driven image generation, current models often deviate from the reference identities and struggle in complex scenes with multiple subjects. To address this challenge, we introduce OpenSubject, a video-derived large-scale corpus with 2.5M samples and 4.35M images for subject-driven generation and manipulation. The dataset is built with a four-stage pipeline that exploits cross-frame identity priors. (i) Video Curation. We apply resolution and aesthetic filtering to obtain high-quality clips. (ii) Cross-Frame Subject Mining and Pairing. We utilize vision-language model (VLM)-based category consensus, local grounding, and diversity-aware pairing to select image pairs. (iii) Identity-Preserving Reference Image Synthesis. We introduce segmentation map-guided outpainting to synthesize the input images for subject-driven generation and box-guided inpainting to generate input images for subject-driven manipulation, together with geometry-aware augmentations and irregular boundary erosion. (iv) Verification and Captioning. We utilize a VLM to validate synthesized samples, re-synthesize failed samples based on stage (iii), and then construct short and long captions. In addition, we introduce a benchmark covering subject-driven generation and manipulation, and then evaluate identity fidelity, prompt adherence, manipulation consistency, and background consistency with a VLM judge. Extensive experiments show that training with OpenSubject improves generation and manipulation performance, particularly in complex scenes.