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arXiv 提交日期: 2026-02-17
📄 Abstract - Exploring the Utility of MALDI-TOF Mass Spectrometry and Antimicrobial Resistance in Hospital Outbreak Detection

Accurate and timely identification of hospital outbreak clusters is crucial for preventing the spread of infections that have epidemic potential. While assessing pathogen similarity through whole genome sequencing (WGS) is considered the gold standard for outbreak detection, its high cost and lengthy turnaround time preclude routine implementation in clinical laboratories. We explore the utility of two rapid and cost-effective alternatives to WGS, matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry and antimicrobial resistance (AR) patterns. We develop a machine learning framework that extracts informative representations from MALDI-TOF spectra and AR patterns for outbreak detection and explore their fusion. Through multi-species analyses, we demonstrate that in some cases MALDI-TOF and AR have the potential to reduce reliance on WGS, enabling more accessible and rapid outbreak surveillance.

顶级标签: medical machine learning systems
详细标签: outbreak detection maldi-tof antimicrobial resistance clinical surveillance multi-species analysis 或 搜索:

探索MALDI-TOF质谱与抗菌药物耐药性在医院疫情暴发检测中的应用 / Exploring the Utility of MALDI-TOF Mass Spectrometry and Antimicrobial Resistance in Hospital Outbreak Detection


1️⃣ 一句话总结

这项研究开发了一种机器学习框架,利用快速、低成本的MALDI-TOF质谱和抗菌药耐药性数据来检测医院疫情暴发,为替代昂贵且耗时的全基因组测序提供了可行方案。

源自 arXiv: 2602.16737