一种用于处理模态缺失的非小细胞肺癌生存预测的对比变分自编码器 / A Contrastive Variational AutoEncoder for NSCLC Survival Prediction with Missing Modalities
1️⃣ 一句话总结
这篇论文提出了一种新的多模态深度学习模型,它能够像拼图一样,即使面对患者部分检查数据(如病理图像、基因数据)严重缺失的情况,也能通过对比学习和不确定性建模,稳健地预测非小细胞肺癌患者的生存期。
Predicting survival outcomes for non-small cell lung cancer (NSCLC) patients is challenging due to the different individual prognostic features. This task can benefit from the integration of whole-slide images, bulk transcriptomics, and DNA methylation, which offer complementary views of the patient's condition at diagnosis. However, real-world clinical datasets are often incomplete, with entire modalities missing for a significant fraction of patients. State-of-the-art models rely on available data to create patient-level representations or use generative models to infer missing modalities, but they lack robustness in cases of severe missingness. We propose a Multimodal Contrastive Variational AutoEncoder (MCVAE) to address this issue: modality-specific variational encoders capture the uncertainty in each data source, and a fusion bottleneck with learned gating mechanisms is introduced to normalize the contributions from present modalities. We propose a multi-task objective that combines survival loss and reconstruction loss to regularize patient representations, along with a cross-modal contrastive loss that enforces cross-modal alignment in the latent space. During training, we apply stochastic modality masking to improve the robustness to arbitrary missingness patterns. Extensive evaluations on the TCGA-LUAD (n=475) and TCGA-LUSC (n=446) datasets demonstrate the efficacy of our approach in predicting disease-specific survival (DSS) and its robustness to severe missingness scenarios compared to two state-of-the-art models. Finally, we bring some clarifications on multimodal integration by testing our model on all subsets of modalities, finding that integration is not always beneficial to the task.
一种用于处理模态缺失的非小细胞肺癌生存预测的对比变分自编码器 / A Contrastive Variational AutoEncoder for NSCLC Survival Prediction with Missing Modalities
这篇论文提出了一种新的多模态深度学习模型,它能够像拼图一样,即使面对患者部分检查数据(如病理图像、基因数据)严重缺失的情况,也能通过对比学习和不确定性建模,稳健地预测非小细胞肺癌患者的生存期。
源自 arXiv: 2602.17402