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arXiv 提交日期: 2026-02-25
📄 Abstract - Enabling clinical use of foundation models in histopathology

Foundation models in histopathology are expected to facilitate the development of high-performing and generalisable deep learning systems. However, current models capture not only biologically relevant features, but also pre-analytic and scanner-specific variation that bias the predictions of task-specific models trained from the foundation model features. Here we show that introducing novel robustness losses during training of downstream task-specific models reduces sensitivity to technical variability. A purpose-designed comprehensive experimentation setup with 27,042 WSIs from 6155 patients is used to train thousands of models from the features of eight popular foundation models for computational pathology. In addition to a substantial improvement in robustness, we observe that prediction accuracy improves by focusing on biologically relevant features. Our approach successfully mitigates robustness issues of foundation models for computational pathology without retraining the foundation models themselves, enabling development of robust computational pathology models applicable to real-world data in routine clinical practice.

顶级标签: medical model training model evaluation
详细标签: histopathology foundation models robustness clinical deployment computational pathology 或 搜索:

实现组织病理学基础模型在临床中的应用 / Enabling clinical use of foundation models in histopathology


1️⃣ 一句话总结

这项研究提出了一种新方法,通过在训练下游任务模型时引入专门的鲁棒性损失,有效减少了组织病理学基础模型对技术性干扰(如扫描仪差异)的敏感性,从而提升了模型在真实临床数据中的准确性和适用性,无需重新训练基础模型本身。

源自 arXiv: 2602.22347