菜单

关于 🐙 GitHub
arXiv 提交日期: 2026-02-26
📄 Abstract - Chain of Flow: A Foundational Generative Framework for ECG-to-4D Cardiac Digital Twins

A clinically actionable Cardiac Digital Twin (CDT) should reconstruct individualised cardiac anatomy and physiology, update its internal state from multimodal signals, and enable a broad range of downstream simulations beyond isolated tasks. However, existing CDT frameworks remain limited to task-specific predictors rather than building a patient-specific, manipulable virtual heart. In this work, we introduce Chain of Flow (COF), a foundational ECG-driven generative framework that reconstructs full 4D cardiac structure and motion from a single cardiac cycle. The method integrates cine-CMR and 12-lead ECG during training to learn a unified representation of cardiac geometry, electrophysiology, and motion dynamics. We evaluate Chain of Flow on diverse cohorts and demonstrate accurate recovery of cardiac anatomy, chamber-wise function, and dynamic motion patterns. The reconstructed 4D hearts further support downstream CDT tasks such as volumetry, regional function analysis, and virtual cine synthesis. By enabling full 4D organ reconstruction directly from ECG, COF transforms cardiac digital twins from narrow predictive models into fully generative, patient-specific virtual hearts. Code will be released after review.

顶级标签: medical multi-modal model training
详细标签: cardiac digital twin ecg-to-4d generative modeling cardiac motion reconstruction medical imaging 或 搜索:

流链:一种从心电信号生成4D心脏数字孪生的基础性框架 / Chain of Flow: A Foundational Generative Framework for ECG-to-4D Cardiac Digital Twins


1️⃣ 一句话总结

这篇论文提出了一个名为‘流链’的基础性生成框架,它能够仅凭一段心电信号就重建出患者个性化的、包含完整结构和动态运动的4D心脏数字孪生,从而将心脏数字孪生从单一任务的预测模型转变为可广泛用于模拟和分析的虚拟心脏。

源自 arXiv: 2602.22919