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Recent work has shown that Transformers can perform in-context learning for linear regression under restrictive assumptions, including i.i.d. data, Gaussian noise, and Gaussian regression coefficients. However, real-world data often violate these assumptions: the distributions of inputs, noise, and coefficients are typically unknown, non-Gaussian, and may exhibit dependency across the prompt. This raises a fundamental question: can Transformers learn effectively in-context under realistic distributional uncertainty? We study in-context learning for noisy linear regression under a broad range of distributional shifts, including non-Gaussian coefficients, heavy-tailed noise, and non-i.i.d. prompts. We compare Transformers against classical baselines that are optimal or suboptimal under the corresponding maximum-likelihood criteria. Across all settings, Transformers consistently match or outperform these baselines, demonstrating robust in-context adaptation beyond classical estimators.