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Recent Vision Language Models (VLMs) have demonstrated strong performance across a wide range of multimodal reasoning tasks. This raises the question of whether such general-purpose models can also address specialized visual recognition problems such as isolated sign language recognition (ISLR) without task-specific training. In this work, we investigate the capability of modern VLMs to perform ISLR in a zero-shot setting. We evaluate several open-source and proprietary VLMs on the WLASL300 benchmark. Our experiments show that, under prompt-only zero-shot inference, current open-source VLMs remain far behind classic supervised ISLR classifiers by a wide margin. However, follow-up experiments reveal that these models capture partial visual-semantic alignment between signs and text descriptions. Larger proprietary models achieve substantially higher accuracy, highlighting the importance of model scale and training data diversity. All our code is publicly available on GitHub.