菜单

关于 🐙 GitHub
arXiv 提交日期: 2026-04-10
📄 Abstract - Neuro-Oracle: A Trajectory-Aware Agentic RAG Framework for Interpretable Epilepsy Surgical Prognosis

Predicting post-surgical seizure outcomes in pharmacoresistant epilepsy is a clinical challenge. Conventional deep-learning approaches operate on static, single-timepoint pre-operative scans, omitting longitudinal morphological changes. We propose \emph{Neuro-Oracle}, a three-stage framework that: (i) distils pre-to-post-operative MRI changes into a compact 512-dimensional trajectory vector using a 3D Siamese contrastive encoder; (ii) retrieves historically similar surgical trajectories from a population archive via nearest-neighbour search; and (iii) synthesises a natural-language prognosis grounded in the retrieved evidence using a quantized Llama-3-8B reasoning agent. Evaluations are conducted on the public EPISURG dataset ($N{=}268$ longitudinally paired cases) using five-fold stratified cross-validation. Since ground-truth seizure-freedom scores are unavailable, we utilize a clinical proxy label based on the resection type. We acknowledge that the network representations may potentially learn the anatomical features of the resection cavities (i.e., temporal versus non-temporal locations) rather than true prognostic morphometry. Our current evaluation thus serves mainly as a proof-of-concept for the trajectory-aware retrieval architecture. Trajectory-based classifiers achieve AUC values between 0.834 and 0.905, compared with 0.793 for a single-timepoint ResNet-50 baseline. The Neuro-Oracle agent (M5) matches the AUC of purely discriminative trajectory classifiers (0.867) while producing structured justifications with zero observed hallucinations under our audit protocol. A Siamese Diversity Ensemble (M6) of trajectory-space classifiers attains an AUC of 0.905 without language-model overhead.

顶级标签: medical multi-modal agents
详细标签: medical prognosis retrieval-augmented generation trajectory analysis neuroimaging interpretable ai 或 搜索:

神经预言家:一种用于可解释癫痫手术预后预测的、基于轨迹感知的智能检索增强生成框架 / Neuro-Oracle: A Trajectory-Aware Agentic RAG Framework for Interpretable Epilepsy Surgical Prognosis


1️⃣ 一句话总结

这篇论文提出了一个名为‘神经预言家’的智能框架,它通过分析病人手术前后大脑核磁共振图像的动态变化轨迹,并结合历史相似病例进行推理,来预测癫痫手术后的康复效果,同时还能生成易于理解的解释性报告。

源自 arXiv: 2604.14216