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Color constancy is a fundamental ability of many biological visual systems and a crucial step in computer imaging systems. Bio-inspired modeling offers a promising way to elucidate the computational principles underlying color constancy and to develop efficient computational methods. However, bio-inspired methods for color constancy remain underexplored and lack a comprehensive analysis. This paper presents a comprehensive technical framework that integrates biological mechanisms, computational theory, and algorithmic implementation for bio-inspired color constancy. Specifically, we systematically revisit the computational theory of biological color constancy, which shows that illuminant estimation can be reduced to the task of gray-anchor (pixel or surface) detection in early vision. Subsequently, typical gray-pixel detection methods, including Gray-Pixel and Grayness-Index, are reinterpreted within a unified theoretical framework with the Lambertian reflection model and biological color-opponent mechanisms. Finally, we propose a simple learning-based method that couples reflection-model constraints with feature learning to explore the potential of bio-inspired color constancy based on gray-pixel detection. Extensive experiments confirm the effectiveness of gray-pixel detection for color constancy and demonstrate the potential of bio-inspired methods.