通过与临床世界模型交互,在大型语言模型中实现患者动态的代理化 / Agentifying Patient Dynamics within LLMs through Interacting with Clinical World Model
1️⃣ 一句话总结
本文提出SepsisAgent系统,通过将大型语言模型与一个模拟患者病情的“临床世界模型”相结合,让AI学会在治疗脓毒症时先模拟多种方案的效果再做决策,从而显著提升治疗推荐的安全性和有效性。
Sepsis management in the ICU requires sequential treatment decisions under rapidly evolving patient physiology. Although large language models (LLMs) encode broad clinical knowledge and can reason over guidelines, they are not inherently grounded in action-conditioned patient dynamics. We introduce SepsisAgent, a world model-augmented LLM agent for sepsis treatment recommendation. SepsisAgent uses a learned Clinical World Model to simulate patient responses under candidate fluid--vasopressor interventions, and follows a propose--simulate--refine workflow before committing to a prescription. We first show that world-model access alone yields inconsistent LLM decision performance, motivating agent-specific training. We then train SepsisAgent through a three-stage curriculum: patient-dynamics supervised fine-tuning, propose--simulate--refine behavior cloning, and world-model-based agentic reinforcement learning. On MIMIC-IV sepsis trajectories, SepsisAgent outperforms all traditional RL and LLM-based baselines in off-policy value while achieving the best safety profile under guideline adherence and unsafe-action metrics. Further analysis shows that repeated interaction with the Clinical World Model enables the agent to learn regularities in patient evolution, which remain useful even when simulator access is removed.
通过与临床世界模型交互,在大型语言模型中实现患者动态的代理化 / Agentifying Patient Dynamics within LLMs through Interacting with Clinical World Model
本文提出SepsisAgent系统,通过将大型语言模型与一个模拟患者病情的“临床世界模型”相结合,让AI学会在治疗脓毒症时先模拟多种方案的效果再做决策,从而显著提升治疗推荐的安全性和有效性。
源自 arXiv: 2605.14723