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The integration of spatial and spectral information is beneficial to the improvement of change detection performance. However, existing methods cannot efficiently suppress the influences of spatial and spectral differences in unchanged areas. To address these issues, in this paper we propose a content-guided spatial-spectral integration network (CSI-Net) for the fusion of global spatial details and spectral difference information. Specifically, the proposed CSI-Net is composed of a spatial reasoning (SR) module, a spectral difference (SD) module, and a content-guided integration (CGI) module. In the SR module, the spatial information is learned by cascaded graph convolution blocks for global modeling. The SD module is responsible for the extraction of spectral features, by calculating the means and variances of features to reduce the impact of spectral differences in unchanged regions. In addition, in order to integrate the spatial-spectral features efficiently, we design a CGI module to further take advantage of their complementary information. In this module, high-level content information is introduced as a guide for a proper interaction. Due to the efficient spatial-spectral fusion, the proposed CSI-Net can learn the changed features better while achieving a suppression of spectral differences. Experimental results on LEVIR-CD, WHU-CD, and CLCD datasets demonstrate that the proposed CSI-Net produces better performance compared to state-of-the-art methods, and is applicable to different scenarios