基于二维PET/CT投影的时间条件与多时间生存预测在肺癌中的应用 / Time-Conditioned and Multi-Time Survival Prediction from 2D PET/CT Projections in Lung Cancer
1️⃣ 一句话总结
本文通过两种创新的时间建模方法(ATCS和MTS),利用肺癌患者的治疗前PET/CT影像,实现了比传统模型更准确的、可针对不同时间段预测生存概率,有望帮助医生制定更个性化的治疗和随访方案。
Accurate prediction of overall survival (OS) from positron emission tomography/computed tomography (PET/CT) can support personalized treatment and follow-up strategies in oncology. However, the impact of temporal modeling on imaging-based survival prediction remains insufficiently explored. We investigate how different temporal formulations influence survival prediction by developing two complementary approaches: Attention-guided Time-Conditioned Survival (ATCS) and Multi-Time Survival (MTS). We retrospectively analyzed pre-treatment PET/CT images from 848 patients with non-small cell lung cancer (NSCLC), including 556 for model development and 292 for held-out testing. A previously proposed Time-Conditioned Survival (TCS) model was used as a baseline. Models were trained using 5-fold cross-validation and evaluated on the test set using time-dependent area under the curve (AUC) at 6-month intervals from 0.5 to 5 years. Both ATCS and MTS outperformed the baseline TCS model, achieving mean AUCs of 0.794 and 0.793, respectively, compared to 0.767. ATCS performed better at earlier time points (0.5-3 years), whereas MTS performed better at later intervals (3.5-5 years). Combining tumor-specific and tissue-wise PET/CT features improved performance over either input alone. Finer temporal discretization improved short-term prediction, while coarser intervals provided more stable long-term estimates. These findings demonstrate that temporal modeling and input design influence PET/CT-based survival prediction. The proposed approaches enable time-specific survival estimation from pre-treatment imaging and may support improved risk stratification and clinical decision-making.
基于二维PET/CT投影的时间条件与多时间生存预测在肺癌中的应用 / Time-Conditioned and Multi-Time Survival Prediction from 2D PET/CT Projections in Lung Cancer
本文通过两种创新的时间建模方法(ATCS和MTS),利用肺癌患者的治疗前PET/CT影像,实现了比传统模型更准确的、可针对不同时间段预测生存概率,有望帮助医生制定更个性化的治疗和随访方案。
源自 arXiv: 2606.12140