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In this paper, two novel data-driven models based on kriging and neural networks (NN) are proposed to predict pressure losses across perforated plates with circular perforations in turbulent flows. The models are developed using two sets of experimental data available in the literature. The predictive performance of the proposed models is assessed and compared against widely used empirical formulae. It is found that the proposed models consistently outperform existing empirical models for most perforated plate configurations contained in the experimental datasets. Besides, the predicted pressure losses generally show good agreement with experimental measurements, demonstrating that data-driven approaches based on kriging and NN provide a feasible framework for modelling pressure losses across perforated plates. Overall, both approaches are promising, despite being trained on a relatively limited amount of experimental data, owing to the scarcity of measurements reported in the literature. To demonstrate the applicability of the proposed models in numerical simulations, two-dimensional channel flows are simulated using the Reynolds-averaged Navier-Stokes (RANS) equations, in which the new pressure-loss models are implemented as a source term in the momentum equations. The RANS predictions are found to be in excellent agreement with the model predictions, confirming the suitability of the proposed approaches for practical computational fluid dynamics applications.