蛋白质网络的事件嵌入:生物功能的组合式学习 / Event Embedding of Protein Networks : Compositional Learning of Biological Function
1️⃣ 一句话总结
这项研究表明,在蛋白质相互作用网络的嵌入学习中,强制使用组合式结构(Event2Vec模型)能比传统方法(如DeepWalk)更有效地捕捉蛋白质之间的功能关联和通路层次关系,特别适用于需要组合推理的生物信息学任务。
In this work, we study whether enforcing strict compositional structure in sequence embeddings yields meaningful geometric organization when applied to protein-protein interaction networks. Using Event2Vec, an additive sequence embedding model, we train 64-dimensional representations on random walks from the human STRING interactome, and compare against a DeepWalk baseline based on Word2Vec, trained on the same walks. We find that compositional structure substantially improves pathway coherence (30.2$\times$ vs 2.9$\times$ above random), functional analogy accuracy (mean similarity 0.966 vs 0.650), and hierarchical pathway organization, while geometric properties such as norm--degree anticorrelation are shared with or exceeded by the non-compositional baseline. These results indicate that enforced compositionality specifically benefits relational and compositional reasoning tasks in biological networks.
蛋白质网络的事件嵌入:生物功能的组合式学习 / Event Embedding of Protein Networks : Compositional Learning of Biological Function
这项研究表明,在蛋白质相互作用网络的嵌入学习中,强制使用组合式结构(Event2Vec模型)能比传统方法(如DeepWalk)更有效地捕捉蛋白质之间的功能关联和通路层次关系,特别适用于需要组合推理的生物信息学任务。
源自 arXiv: 2604.00911