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Reliable autonomous driving relies on large-scale, well-labeled data and robust models. However, manual data collection is resource-intensive, and traditional simulation suffers from a persistent reality gap. While recent generative frameworks and radiance-field methods improve visual fidelity, they still struggle with temporal and spatial consistency and cannot ensure physics-aware behavior, limiting their applicability to driving scenario generation. To address these challenges, we propose Real2Sim, an unified framework that combines 4D Gaussian Splatting (4DGS) with a differentiable Material Point Method (MPM) solver. Real2Sim explicitly reconstructs dynamic driving scenes as temporally continuous Gaussian primitives, supports instance-level editing, and simulates realistic object-object and object-environment interactions. This framework enables physics-aware, high-fidelity synthesis of diverse, editable scenarios, including challenging corner cases such as collisions and post-impact trajectories. Experiments on the Waymo Open Dataset validate Real2Sim's capabilities in rendering, reconstruction, editing, and physics simulation, demonstrating its potential as a scalable tool for data generation in downstream tasks such as perception, tracking, trajectory prediction, and end-to-end policy learning.